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66 Targeting multiple peptide hormone receptors with the same drug entity appears to be the most promising strategy, where additive, or even synergistic, benefits of simultaneously activating two receptor signalling pathways in bone can be fully realised

Wessells et al., J

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Thyroid hormone over-replacement is associated with increased risks of atrial fibrillation or flutter (AF/Aflutter) and stroke, especially in older individuals with T2D and obesitypopulations already at elevated cardiovascular risk [30,31,32,33,34,35]