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Conventional delivery of antioxidants faces several challenges, including poor bioavailability, low stability, rapid clearance, short half-life, poor targeting, non-specific distribution, gastrointestinal degradation, low penetration of biological barriers, cytotoxicity, and pro-oxidant effects at high doses [31]

Intravenous iron therapy is generally reserved for severe iron deficiency, although one study showed no difference in the efficacy of intravenous iron therapy compared to treatment with oral iron in the form of ferrous fumarate (Garrido-Martin 2012)

The change was made to better reflect the underlying factors of MASLD (however, we use these terms interchangeably throughout this article)

Gu et al., 2014