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Defining the correlation between immune-checkpoint inhibitors-related adverse events and clinical outcomes: a narrative review Omar Abdihamid 1 , Abeid Omar 2 and Tibera Rugambwa 3 1 Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, Peoples Republic of China 2 Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University, Champlion Street, Alazarita, Alexandria 21131, Egypt 3 Department of Internal Medicine, Mbeya Zonal Referral Hospital, Mbeya 419, Tanzania Abstract Immune checkpoint inhibitors (ICIs) have increased modern anticancer armamentarium portfolios, with 15%60% of cancer patients deriving clinical benefit while others progress, including some occurrences of accelerated progressions

Segn el influyente artculoThe Hallmarks of Aging, la disfuncin mitocondrial se considera uno de los procesos biolgicos fundamentales implicados en el propio envejecimiento