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These findings were proved in the PIVENS trial, which compared low-dose pioglitazone versus a placebo for 2 years in patients without overt diabetes [30], as well as in another placebo-controlled trial including subjects with NASH for whom diet and pioglitazone improved glycemic control and glucose tolerance, normalized liver aminotransferase levels, decreased hepatic fat content, and increased hepatic insulin sensitivity [31] (Table 1)

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"L-carnitine supplementation in patients with advanced cancer and carnitine deficiency: a double-blind, placebo-controlled study." J Pain Symptom Manage 37(4): 622-631

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