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L-carnitine and its derivative ALCAR are supported by evidence as effective interventions for managing chronic neuropathic pain, with mechanisms involving nerve regeneration, neurotrophic factor modulation, and mitochondrial function enhancement

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Acetylcholine The cholinergic-adrenergic hypothesis of mood disorders, specifically the role of increased cholinergic activity in modulating depressed mood and sleep disturbance, has been supported by preclinical and human pharmacologic studies [212, 213]

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