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Saffron increased several short-chain-fatty-acidproducing genera and the researchers noted some correlations between microbiota changes and sleep parameters, but the study was too preliminary to allow clear conclusions about the extent to which saffrons effects on sleep are mediated by changes in the gut microbiota

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Majori M, Vachier I, Godard P, Farce M, Bousquet J, Chanez P: Superoxide anion production by monocytes of corticosteroid-treated asthmatic patients

One major concern is that CHAC1 plays a critical role in regulating oxidative stress, GSHdegradation, and ferroptosis, essential processes for cellular redox homeostasis