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Sustained IGF-1 elevation over weeks is the explicit pharmacodynamic effect, and preliminary evidence suggests this is the same axis implicated in insulin resistance and water retention at higher cumulative exposures

[1] In terms of efficacy, ipamorelin has similar or higher potency compared to GHRP-6 in various animal models, but it stands out due to its unique lack of effect on other hormones such as prolactin, follicle stimulating hormone (FSH), luteinizing hormone (LH), PRL, and thyroid stimulating hormone (TSH)

For anyone on these medications, the takeaway is consistent with what physicians have long recommended: a GLP-1 prescription works best as part of a broader, long-term approach to weight management, not a standalone solution

In promotional materials, companies cannot claim that non-FDA-approved compounded products are generic versions or the same as drugs approved by FDA