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Tolerability: According to a study, semaglutide was associated with a lower rate of discontinuation due to side effects compared to other GLP-1 medications like liraglutide, making it better tolerated over the long term

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Studies of patients who used GLP-1 for 6 to 12 months showed that those who adopted sustainable eating patterns and exercise retained 40 to 60 percent of their loss after stopping, while those who reverted to pre-treatment habits regained most weight within 12 to 18 months

Transition to the glucagon-bound state requires the lid-like -sheet module to undergo a major conformational change