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Figure 1 Given that the E4 allele is associated with both an increased reliance on alternative fuels, such as FAs, and more severe cerebrovascular dysfunction with age (Yassine and Finch, 2020

Furthermore, evidence shows that most (up to 95%) pharmaceutical drugs found effective and safe in animal studies fail in subsequent clinical phases in human populations, mainly due to insufficient efficacy, toxicity, and the emergence of unacceptable adverse drug reactions, raising significant concerns for ethical and economic reasons (204211)

Brookens, S

The activities of PAL, CAD, and POD all increased accordingly, thus accelerating the synthesis of lignin