The LEADER trial (liraglutide) and SUSTAIN-6 trial (semaglutide) demonstrated cardiovascular risk reduction over multi-year follow-up periods (approximately 3.8 years and 2.1 years, respectively)
Some things that semaglutide therapy does to the body once you take it include: Delayed stomach emptying, leading to a feeling of fullness and satiated hunger from smaller portion sizes Low blood sugars through the reduction of sugar production in the liver Slowed gastrointestinal (GI) motility, which refers to the movement of food through your GI system, involves your throat, esophagus, stomach, and intestines Improves insulin sensitivity, helping our body use blood sugar more efficiently rather than storing it as fat Semaglutide is typically administered via injection under the skin of your stomach, thighs, or upper arm
Curcumin shows similar potential in animal models
Therefore, health plans can consider removing GLP-1 coverage for weight loss while covering other, less expensive options