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doi:10.1007/s00125-010-1937-z Lauffer L, Grieco A, Iakoubov R, Brubaker PL (2009) Metformin activates the AMPK pathway and improves survival of murine and human L-cells but does not directly increase GLP-1 secretion

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In the longevity context, researchers are actively studying metformin's potential associations with metabolic health pathways, cellular aging processes, and mortality risk - most notably through the TAME (Targeting Aging with Metformin) trial