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Potential mild effects observed in animal and in vitro models include transient fatigue, mild nausea, or digestive discomfort related to metabolic acceleration

Those with naturally high NNMT activity might respond more dramatically to inhibition, while those with lower baseline activity might see more modest effects

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[4] In differentiated 3T3-L1 mouse adipocytes, 5-Amino-1MQ lowered intracellular 1-MNA in a concentration-dependent manner with an EC 50 of 2.3 1.1 M (R = 0.94)