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Chen et al., Complications SCD causes a wide range of complications in various of the body's systems, shown in Figure 2, including the cardiovascular, reproductive, pulmonary, renal, hepatobiliary, and can even cause neurocognitive dysfunction (Kato et al., Figure 2 The clinical hallmark and primary cause of SCD hospitalisations are vaso-occlusive crises (VOCs) (Rees et al., Disease-Modifying Drugs Hydroxyurea Hydroxyurea acts as an inhibitor of ribonucleotide reductase, thereby inactivating enzymes involved in cellular division (Inusa et al., 1976

This absence of approval is echoed by regulatory agencies in countries like the UK, Canada, and Australia

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Pratt, 1999