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Journal of Pharmacy and Pharmacology, 77 (2), 206-221

Weight loss injections, particularly GLP-1 receptor agonists like semaglutide (Wegovy) and dual GIP/GLP-1 receptor agonists such as tirzepatide (Zepbound), can cause vomiting as a common side effect

label notes that neurons expressing MC4R are present in many areas of the central nervous system, but the precise mechanism for improving HSDD is unknown