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On the other hand, mounting evidence suggests an association between chronic sleep fragmentation and cyclical episodes of hypoxia-reoxygenation with systemic inflammation, oxidative stress, sympathetic activation, hypothalamic-pituitary axis stimulation, adipokine dysregulation, and increased risk for weight gain
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The rules are specific: required for E11 and E13, not required for E10, and strictly limited to ongoing therapy rather than temporary glucose management
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