The backbone of the master network comprises DEPs/metabolics, including NFKB1, CTNNB1, ALB, peroxides, NOS2, TNF, and IL-6, while in the giant network, many redox-related enzymes were predicted to be hubs, including endothelial NO synthase producing NO relaxing smooth muscle relaxation (NOS3), mitochondrial superoxide dismutase 2 (SOD2), and peroxiredoxin 6 (PRDX6) (catalyzes the reduction of hydrogen peroxides)
A mice model of immune ovarian failure (32) where, a factor NF-kappa B leading to pro-inflammatory factors secretion, triggers the follicular cell death, curcumin has been shown to: attenuate the inflammatory response
In pharmaceutical compounding, buffers usually consist of a weak acid and its conjugate base, or a weak base and its conjugate acid
however, Grxs are more versatile than Trxs in terms of their substrate selectivity and reaction mechanisms [16]