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It is a necessary co-factor for the body to actually use collagen to repair tissue, and it helps your body recycle glutathione

The pattern is consistent with the Pei 2024 meta-analysis which found cumulative benefits from repeated microneedling sessions

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A recent study including spontaneously hypertensive rats and controls (WKY) reported that UA therapy (16 mg/kg) induced Kruppel-like factor 2 (KLF2) expression, lowered vascular endothelial growth factor (VEGF)-A levels, reduced BBB leakage, and improved endothelial cell barrier integrity [194, 196]