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E., Slater, L

And, in terms of nutrition, theres evidence that eating a high-fat, high-sugar diet can interfere with your cellular NAD levels and, in turn, mitochondrial function

doi: 10.1016/j.brainres.2005.03.011, 2 AranasC.EdvardssonC

In human studies, nitrate supplementation produces significant hemodynamic benefits, including lower systolic BP (SBP) and diastolic BP (DBP), improved endothelial function, and reduced arterial stiffness, with evidence of enhanced oxygen delivery/mitochondrial efficiency in muscle