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Compared to steroids, effects are more modest but with potentially fewer side effects and easier recovery

Summary: True vitamin B12 overdose is exceptionally rare because it is water-soluble and excess amounts are excreted through urine rather than accumulating in body tissues

It was proposed that GLP-1 RAs may exert antihypertensive effects through improved endothelial function, modulation of smooth muscle cell phenotype, promotion of weight loss, stimulation of GLP-1 receptors, and induction of a natriuretic effect

Homogenates were centrifuged at 800 g for 10 min at 4 C, and the supernatant was sonicated on ice for 20 s before protein quantification (BCA protein assay, Pierce, Rockford, IL, USA)