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How the EU Handles Biosimilar Substitution Without an Interchangeability Designation The EMA has no statutory interchangeability designation

Pull the plunger back to draw air into the syringe equal to the volume of medication you will withdraw (this air injection technique prevents vacuum buildup in the vial that makes withdrawal difficult)

Since vagal tone is involved in inflammatory responses and pain modulation, excessive stimulation or dysregulation of this pathway may contribute to heightened pain perception