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Figure 1 VNS modulates PD pathology through two synergistic pathways: (1) Peripheral (Gut) Effects: Reshapes gut microbiota composition and metabolites ( LPS, SCFAs), reduces intestinal inflammation and -Syn expression, and inhibits -Syn propagation to the CNS via the VN

To determine dose level and dose frequency of central administration of mGIPR-Ab, pharmacokinetic profile of ( a ) brain and ( b ) plasma exposure was assessed at 4, 24, 72, 120, and 168 h following a single ICV injection of 15 g/L/mouse dose of mGIPR-Ab

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Taken together, results from these trials showed that more patients treated with Bimzelx saw at least a 50% improvement in the signs and symptoms of hidradenitis suppurativa at 16 weeks, as compared with placebo