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While many associations exist between bilirubin and blood vessels and smooth muscle, studies addressing bilirubins effect on tumor vasculature and smooth muscle tumors are scarce and require further study

For example, whether mesangial cell ferroptosis contributes to glomerulosclerosis (a core pathological feature of LN) or if tubular epithelial cell ferroptosis amplifies renal inflammation and fibrosis in LN has not been rigorously characterized

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Thus, although some of the damage in this experimental model of colitis reflects a direct erosive effect of TNBS and ethanol, their combined administration to rats reflects the in vivo operation of the damaging mechanisms elicited by TNBS, namely GSH depletion and ROS generation, indicating that ethanol facilitates the access of TNBS to the cell interior ensuring TNBS-induced GSH depletion and ROS generation