Nagel, Jonas Binder, Michael Sztucki, Wolfgang Friess, Tim Menzen, Gerhard Winter, Evgenyi Shalaev #Pharmaceuticals #ProteinStability #FreezeDrying #SAXS #Biophysics #OpenScience To view or add a comment, sign in In the phase 3 ACHIEVE clinical trial, Eli Lilly's orforglipron (an oral glucagon-like peptide 1 [GLP-1] receptor agonist) outperformed semaglutide in lowering A1C levels and promoting weight loss over 52 weeks
Tirzepatide (Mounjaro, Zepbound) tends to produce greater weight loss than semaglutide (Ozempic, Wegovy), which may mean more aggressive caloric restriction and potentially larger nutritional gaps
Reduces Collagenolytic Activity: The body begins to lose collagen every year from the early 20s, leading to a decrease in skin firmness & elasticity
Acknowledgements The authors thank Prof