This is an important study because its the first time a weight loss drug has been shown to reduce the risk of heart disease, including the risk of death, says Howard Weintraub, MD, clinical director of the Center for the Prevention of Cardiovascular Disease, part of NYU Langone Heart
A review of pivotal clinical trials for semaglutide (STEP, SUSTAIN), dulaglutide (REWIND), liraglutide (LEADER), and tirzepatide (SURPASS, SURMOUNT) does not identify muscle cramps as occurring at significantly higher rates compared to placebo groups
So you can still inject into thigh, to avoid too much change, but with a shorter thinner needle
Pre-existing risk factors like obesity can also increase abdominal pressure and trigger acid reflux and heartburn