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Potential risks and contraindications Given the limited understanding of DSIPs mechanisms and effects in humans, certain risks and contraindications must be taken into consideration: Unknown long-term effects : The long-term safety of DSIP has not been well-established, and the potential risks associated with chronic use remain unclear

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For example, Kuroki and colleagues found that exendin-4 administration would inhibit the matrix metalloproteinase-9 activation in the animal model, with the suppressing effects persisting at least 7 days [4]