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Administration of 30 mg of propantheline 45 min prior to nitrofurantoin 100 mg administration resulted in a statistically significant increase in nitrofurantoin excretion, however, the clinical significance of this effect is unknown

Long-term dosing studies have also been conducted to evaluate tissue tolerance and inflammation markers, suggesting a favorable profile in terms of local joint impact and systemic safety

But repeated cortisone injections may weaken tendon tissue over time

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