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This results in low vitamin B12 or deficiency and causes abnormally large red blood cells to be produced, which cannot carry oxygen around your body effectively Diet If your diet is lacking in red meat, Fish, meat, eggs, milk, and other dairy or breakfast cereals which also contain vitamin B12, you may develop vitamin B12 deficiency over time

TFAM functions as a downstream effector of PGC-1, regulating mitochondrial biogenesisx

So you have to have some kind of mechanisms

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