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Clinicians must take into account mechanisms of action, level of HbA1c reduction, impact on fasting plasma glucose and/or post-prandial glucose levels, safety and tolerability, effects on weight, route of administration, and finally, cost

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Elective surgery has also long been used as a paradigm of the stress response in humans (188-190): the magnitude of cortisol rise correlates positively with the severity of surgery (191)