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Bupropion, being dopaminergic rather than serotonergic, does not create this antagonistic effect

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Hydration is critically important, as diarrhea can lead to dehydration and electrolyte imbalances

Risk factors include renal impairment, concomitant use of certain drugs, age 65 years old, radiological studies with contrast, surgery and other procedures, hypoxic states, excessive alcohol intake, and hepatic impairment