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Increased oxidant production can promote depletion of nitric oxide by many mechanisms, including the direct reaction of nitric oxide with superoxide to produce peroxynitrite

The first step of glutathione synthesis involves the formation of glutamylcysteine from glutamate and cysteine in an ATP dependent reaction catalysed by glutamate-cysteine-ligase (GCL) which requires either Mg 2+ or Mn 2+ as a cofactor

Ce phnomne est accentu par le tabagisme , la pollution , lexposition aux UV ou aux radiations ionisantes, la consommation daliments frits ou cuits haute temprature ou encore la pratique dune activit physique intense (12)