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As the mission duration for astronauts has increased over the past decades, SANS is becoming increasingly recognised, most prominently noted during 6 to 12-month missions onboard the International Space Station (ISS) [1]

Clusters 2, 4, and 5 were identified as profibrotic lipid-associated macrophages (LAMs) because of high expression of profibrotic genes (Fn1, Spp1, CD44) and lipid metabolism genes (Lpl, Trem2, Fabp4, Fabp5)

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