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They may help mitigate some metabolic adaptation during weight loss, though they don't prevent the natural reduction in metabolic rate that occurs with decreased body mass

This can happen as the medication slows digestion and food remains in the stomach for longer, increasing gas and burping

Younossi ZM, Golabi P, de Avila L, Paik JM, Srishord M, Fukui N, et al

Weight cycling, or losing and then gaining the same weight several times in ones life, is associated with over a 50% increased risk of heart failure and nearly 30% increased risk of type 2 diabetes, sleep apnea, and metabolic liver disease, she told FI