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Human studies show that moderate-intensity aerobic exercise (e.g., 30 min of cycling or walking at 4.5 km/h, three times per week) leads to a notable increase in orexin secretion, contributing to improved mood and reduced depressive symptoms

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[Google Scholar] 48.Manohari SM, Raman V, Mysore A

Diabetes Obes Metab 19(3):33647 Buse JB, Klonoff DC, Nielsen LL, Guan X, Bowlus CL, Holcombe JH et al (2007) Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: An interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials