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This study identifies three classes of epigenetic inhibitors that target melanoma subpopulations with different levels of differentiation to increase their dependence on MAPK signalling, and therefore their sensitivity to BRAF and MEK inhibitors

The clinical significance of these findings is unknown

Wegovy has been known to interact with other medications

To determine which genes drive the differences in transcriptional landscape among the various subclusters, we focused on functionally related genes that exhibited high differential expression between each subcluster within individual endocrine cell populations as well as other known and cell marker genes