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RF microneedling delivers thermal energy into the dermis through micro-channels, triggering a controlled wound healing response and collagen remodeling that tightens and thickens the skin from within

Therefore, the mechanism of blue light induced RPE cell apoptosis is related to oxidative stress, endoplasmic reticulum stress, lysosomal dysfunction, and mitochondrial potential changes

The remaining 76 articles underwent a full-text screening process, during which 38 articles were excluded for the following reasons: 4 wrong focus, 13 cells of animal origin and 21 due to an unfitting cell type

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