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Unlike small-molecule drugs that remain stable across broad temperature ranges, peptides depend on precise spatial arrangement to bind growth hormone secretagogue receptors

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in the Journal of Clinical Endocrinology and Metabolism tested single doses of CJC-1295 in healthy adults and observed dose-dependent increases in mean GH concentrations of 2- to 10-fold for six or more days, and mean IGF-1 concentrations 1.5- to 3-fold for 9 to 11 days, with no serious adverse reactions at the doses studied [6]