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In various non-clinical models, including rodent and primate studies, sema peptide has been observed to reduce body weight through mechanisms involving central satiety pathways and food-motivated behavior

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In the landmark SURMOUNT-1 trial, participants receiving the highest dose of tirzepatide lost an average of 22.5% of their body weight over 72 weeks, making it one of the most effective pharmaceutical weight loss interventions available (Jastreboff et al., 2022, New England Journal of Medicine )

Almeida JR, Modig T, Petersson A, Hhn-Hgerdal B, Lidn G et al (2007) Increased tolerance and conversion of inhibitors in lignocellulosic hydrolysates by Saccharomyces cerevisiae