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In follow-up of these studies, it was shown that Mito-TEMPO, which is highly effective in protecting against APAP toxicity [29], did not reduce LPO or liver injury in animals co-treated with APAP and Fe 2+ [82]

In contrast, cells with lower senescence burden may have less FOXO4p53 dependence, or may buffer p53 relocalization through other regulators, which might explain the limited apoptosis in younger cultures compared to aged cell cultures

E., Seplveda, M

Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant DEFENSE