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The main molecular mechanisms of GLP-1RA in obesity reduction include the increased production of insulin by the cAMP/PKA pathway in pancreatic -cells, along with an augmented translocation of GLUT-4 in the cellular membrane for improved glucose homeostasis, and energy expenditure by lipolytic cycle stimulation

"Pregnancy or intention to become pregnant were exclusion criteria in our trials with semaglutide in both obesity and type 2 diabetes," Novo Nordisk told PEOPLE when contacted for a statement

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