Clinical trials demonstrated that afamelanotide could significantly reduce the pain and phototoxic reactions experienced by EPP patients when exposed to sunlight
Pravat K Mandal, Anshika Goel, Ashley I Bush, Khushboo Punjabi, Shallu Joon, Ritwick Mishra, Manjari Tripathi, Arun Garg, Natasha K Kumar, Pooja Sharma, Deepika Shukla, Scott Jonathan Ayton, Amir Fazlollahi, Joseph C Maroon, Divya Dwivedi, Avantika Samkaria, Kanika Sandal, Kanu Megha, Sandhya Shandilya, Hippocampal glutathione depletion with enhanced iron level in patients with mild cognitive impairment and Alzheimers disease compared with healthy elderly participants, Brain Communications, Volume 4, Issue 5, 2022, fcac215, Watanabe F, Hashizume E, Chan GP, Kamimura A
The Science: How Oral GLP-1 Agents Work GLP-1 (glucagon-like peptide-1) receptor agonists mimic a natural gut hormone that regulates appetite, insulin secretion, and gastric emptying
While some studies suggest benefits, human trials are still lacking