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Weekly medications like semaglutide and dulaglutide have longer half-lives, taking longer to reach steady-state concentrations but offering more stable drug levels throughout the week

Additionally, GLP-1 mitigates H2O2-induced senescence, regulates the antioxidant defense system, reduces cellular senescence, and DNA damage triggered by recurring oxidative stress [82]

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Other side effects to monitor Patients switching between formulations should also be aware of potential headaches associated with GLP-1 therapy , tirzepatide body aches , muscle pain , insomnia , and semaglutide-related sleep disruption