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The result is not that nausea disappears entirely

Patients with pre-existing risk factors, such as diabetes or heart disease, may already have an elevated risk of NAION, making it difficult to determine the drugs direct role

Step 3: If different, recalculate your units using the formula: units = (desired mg / new concentration) x 100 Step 4: Verify with a second calculation method

However, certain symptoms warrant a call to your healthcare provider: Nausea severe enough to prevent eating or drinking for more than 24 hours Persistent vomiting, especially if it continues beyond 24 hours Signs of dehydration (dark urine, dizziness when standing, dry mouth) Severe abdominal pain that does not resolve Diarrhea that continues for more than three days In rare cases, your prescriber may temporarily reduce the tirzepatide dose or pause the dose escalation until GI symptoms resolve