To provide protection against ROS, repair oxidative damage and maintain a reducing intracellular environment, (developing) red cells are equipped with a variety of antioxidants, including superoxide dismutase 1 and 2, catalase, glutathione peroxidase 1, peroxiredoxin I and II, and glutathione (GSH)-synthesizing enzymes (van Zwieten et al., 2014
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Oxidative stress is involved in endothelial damage resulting from endothelial malfunction, which increases endothelial permeability and inflammatory cell infiltration in the arterial wall [69]
