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third, through gene editing and surface modification technologies, the engineered bacteria can actively respond to the pathological microenvironment, maximizing efficacy and reducing the risk of systemic exposure

Abbreviations AD: Autoimmune disease AMP: Antimicrobial peptide ATP: Adenosine triphosphate : Angstroms BfUbb: Bacteroides fragilis Ubiquitin CD: Coeliac disease dsDNA: Double stranded DNA EAST1: Enteroaggregative heat resistant toxin 1 EPEC: Enteropathogenic E