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In C57BL/6 mice, an unrestricted KD with 13E% from protein reduced tumor growth after transplantation of Lewis lung carcinoma cells compared with a high-CHO diet (77E% CHO), and this became significant when protein was further restricted to 5E% and replaced with fat

Because Wegovy (when approved at its highest dose) produces rapid weight loss and sharper metabolic shifts, this could drive the stronger association by predisposing to optic nerve hypoperfusion through intravascular volume contraction, hypotension with nocturnal dips and autonomic instability. For ophthalmologists, the findings highlight a potential safety signal that warrants further investigation but should be interpreted cautiously