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It inhibits ferroptosis by inhibiting the expression of activating transcription factor 3 (ATF3), reducing the levels of lipid ROS and increasing the levels of GSH, which ultimately attenuates IRI- or FA-induced AKI [190]

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Abbreviations: M3, muscarinic acetylcholine receptor subtype 3

This mechanism is consistent with prior findings where Spirulina -derived metabolites promoted Nrf2 activation and reduced oxidative stress in hepatic injury models (Sibiya et al., 2022)