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Several factors may explain why CVOTs have not demonstrated more robust or statistically significant results with combination therapy

Although this view was later attenuated based on the head-to-head conformation of the DNA-bound DBD dimer that was observed in X-ray crystallography studies and observations of relaxed response element stringency for selective chromatin binding [51, 52], it did point to the potential of variability in the composition of AREs and to deviations from the ideal 15 bp sequence

While it is highly effective for many patients, it can also lead to side effects, including skin reactions

Even as MEDVi was generating the kind of revenue that would land it in the New York Times, the relationships powering that growth were already falling apart