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Conjugation proceeds as a nucleophilic displacement reaction with the glutathione anion (GS - ) serving as the nucleophile

Significance was expressed in terms of P value, which was considered significant when it was less than or equal to 0.05

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We demonstrated that GSTM2 protects against hepatic steatosis by inhibiting excess fat accumulation by interacting with and suppressing activation of apoptosis signal-regulating kinase1 ( ASK1 ) and subsequent p38-JNK signalling, besides its antioxidant capacity