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An exploratory subgroup analysis of five PIONEER trials (35, 7, and 8) assessed the potential impact of different background medications (metformin, SU, SGLT2i, insulin, or combinations) on the efficacy and safety of oral semaglutide and comparators [71]

The non-natural environment of cells that grow in a monolayer, while attached to an artificial matrix is a major difference between the native tissue and such cultures, together with the lack of microenvironment provided by the actual tissue architecture [87]

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These observations need to be confirmed in larger, well-designed trials