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2.4.2 Trial 2 (Digoxin/Metformin) Sample Size Calculations Assuming the ratio between AUC values was 1.03, and the number of subjects where both primary endpoints were evaluable was 28, then the combined power of concluding no effect of coadministration of oral semaglutide for both endpoints was at least 95%

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Novo Nordisk submitted CagriSema for FDA approval, with a decision expected in late 2026